Format

Send to

Choose Destination
See comment in PubMed Commons below
Reproduction. 2008 Oct;136(4):387-90. doi: 10.1530/REP-08-0223. Epub 2008 Jul 11.

Identification and spatial distribution of glycine receptor subunits in human sperm.

Author information

  • 1Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616, USA. pkumar@ucdavis.edu

Abstract

The human sperm surface glycine receptor (GLR) plays a role in an important fertilization event, the sperm acrosome reaction. Here, by western blot analysis, we report the presence of GLRA1, GLRA2, GLRA3, and GLRB subunits in human sperm. Immunolocalization studies showed that the GLRA1 and GLRA2 subunits are present in the equatorial region, the GLRA3 subunit in the flagellar principal piece, and the GLRB subunit in the acrosomal region of sperm. This first demonstration of isoforms of the sperm GLRA subunit and of a differential spatial distribution of the alpha and beta subunits on the surface of mammalian sperm suggests the possibility that human sperm GLRs have more than one function.

PMID:
18621921
DOI:
10.1530/REP-08-0223
[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center