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Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9645-50. doi: 10.1073/pnas.0803747105. Epub 2008 Jul 9.

The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like.

Author information

1
Developmental Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

Abstract

The activity of different signaling pathways must be precisely regulated during development to define the final size and pattern of an organ. The Drosophila tumor suppressor genes dachsous (ds) and fat (ft) modulate organ size and pattern formation during imaginal disc development. Recent studies have proposed that Fat acts through the conserved Hippo signaling pathway to repress the expression of cycE, bantam, and diap-1. However, the combined ectopic expression of all of these target genes does not account for the hyperplasic phenotypes and patterning defects displayed by Hippo pathway mutants. Here, we identify the glypicans dally and dally-like as two target genes for both ft and ds acting via the Hippo pathway. Dally and Dally-like modulate organ growth and patterning by regulating the diffusion and efficiency of signaling of several morphogens such as Decapentaplegic, Hedgehog, and Wingless. Our findings therefore provide significant insights into the mechanisms by which mutations in the Hippo pathway genes can simultaneously alter the activity of several signaling pathways, compromising the control of growth and pattern formation.

PMID:
18621676
PMCID:
PMC2474532
DOI:
10.1073/pnas.0803747105
[Indexed for MEDLINE]
Free PMC Article

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