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Ann Diagn Pathol. 2008 Aug;12(4):267-70. doi: 10.1016/j.anndiagpath.2007.02.002. Epub 2007 Oct 3.

Eosinophilic angiocentric fibrosis of the sinonasal tract.

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Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA.


Eosinophilic angiocentric fibrosis (EAF) is an uncommon inflammatory fibrosing lesion of the upper respiratory tract and orbit that occurs mainly in young to middle-aged women. The etiology of EAF is unknown. To our knowledge, approximately 28 cases have been previously reported in the English literature. We report here 3 additional cases of EAF of the sinonasal tract; 2 in women aged 19 and 31 years, and 1 in a man aged 49 years. The 19-year-old woman is the youngest patient with EAF ever described. The patients presented with a nasal cavity mass, face pain, or nasal obstructive symptoms of long duration.

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