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Expert Opin Ther Targets. 2008 Aug;12(8):917-20. doi: 10.1517/14728222.12.8.917 .

Relationship between plasma osteopontin and oxidative stress in patients with coronary artery disease.

Author information

1
University of Athens, Second University Department of Cardiology, Medical School, Attikon General Hospital, 1 Rimini Street 124 62, Athens, Greece. pg171@hlk.forthnet.gr

Abstract

BACKGROUND:

It is known that oxidative stress plays an important role in the pathogenesis of atherosclerosis and that an association exists between osteopontin (OPN) and atherosclerosis.

OBJECTIVES:

It was proposed that malondialdehyde (MDA), a biomarker of lipid peroxidation and oxidative stress, would be related to plasma OPN levels in patients with coronary artery disease (CAD).

METHODS/RESULTS:

Plasma OPN and MDA levels were measured in 71 patients (60 males and 11 females; mean age 61.7 +/- 10 years). Fifty-eight patients had significant CAD (group I) and 13 patients were free of CAD as defined angiographically (group II). Plasma OPN was measured by enzyme-linked immunosorbent assay (ELISA), while MDA was determined spectrophotometrically. Multivariate regression analysis revealed that ln-transformed OPN levels were independently associated with MDA after adjustment for age, hypertension and diabetes mellitus (R(2) = 0.278, p = 0.0004 and beta regression coefficient = 0.252 [standard error = 0.0958], p = 0.011). OPN and MDA levels were higher in patients with diabetes (73.6 +/- 36.2 ng/ml versus 56.1 +/- 30.9 ng/ml, p = 0.02 and 2.5 +/- 0.5 microM versus 2.0 +/- 0.5 microM, p = 0.002, respectively).

CONCLUSIONS:

The association between OPN and MDA levels in patients with CAD suggests an interaction between OPN and oxidative stress. This interaction may play a role in the pathogenesis of atherosclerosis.

PMID:
18620515
DOI:
10.1517/14728222.12.8.917
[Indexed for MEDLINE]

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