Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 2008 Sep 4;591(1-3):128-31. doi: 10.1016/j.ejphar.2008.06.079. Epub 2008 Jun 27.

Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1).

Author information

1
Bosch Institute, The University of Sydney, New South Wales, Australia.

Abstract

The ATP-binding cassette (ABC) transporter ABCC1, or multidrug resistance-related protein 1 (MRP1) is implicated in Phase II metabolism and multidrug resistance as it effluxes substrate anticancer drugs. As cannabinoids inhibit two related ABC transporters, P-glycoprotein and ABCG2, here we examined whether they also inhibit ABCC1. Indeed, the cannabinoids enhanced the intracellular accumulation of two ABCC1 substrates, Fluo3 and vincristine, in ovarian carcinoma cells over-expressing ABCC1 (2008/MRP1) with a rank order of potency: cannabidiol>cannabinol>Delta(9)-tetrahydrocannabinol. Cannabinoid inhibition of ABCC1 was confirmed using insect cell membrane MRP1 ATPase assays. These results demonstrate that cannabinoids inhibit ABCC1.

PMID:
18619955
DOI:
10.1016/j.ejphar.2008.06.079
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center