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Transfus Apher Sci. 2008 Aug;39(1):59-67. doi: 10.1016/j.transci.2008.05.006. Epub 2008 Jul 10.

Prion safety of transfusion plasma and plasma-derivatives typically used for prophylactic treatment.

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Octapharma Pharmazeutika Produktionsges.m.b.H, Pre-Clinical Research and Development Department, Oberlaaerstrasse 235, Vienna, Austria.


Reports about transfusion-related transmissions of variant Creutzfeldt-Jakob disease have urged the need for more information regarding the risk for prion contaminated units in the blood supply and the safety of transfusion plasma and biopharmaceuticals derived from this precious raw material. According to a possible epidemiological model, the risk in many European countries is the same or lower than that of human immunodeficiency virus. Comprehensive investigations have shown that the prion safety margin of both single-donor and pooled solvent/detergent treated transfusion plasma is high. Furthermore, prophylactic treatment using plasma-derivatives poses a very low risk in terms of prion disease despite extensive lifetime exposure.

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