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J Enzyme Inhib Med Chem. 2009 Feb;24(1):136-9. doi: 10.1080/14756360801936399 .

Antidiabetic effect of an active fraction extracted from dragon's blood (Dracaena Cochinchinensis).

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1
School of Life Sciences, Shanghai University, Shanghai, China.

Abstract

The active fraction extracted from dragon's blood displayed an inhibitory effect on alpha-glucosidase activity with an IC50 of 0.152 microg/mL, which is nearly half of the crude material. Its inhibition on alpha-glucosidase was noncompetitive. In addition, when this fraction was orally administered to mice dosed with Acarbose (20 mg/kg), the active fraction (100, 300, 500 mg/kg) significantly suppressed increase of blood glucose levels after sucrose loading in a dose-dependent manner. These results suggest that this extract from dragon's blood exerts an anti-diabetic effect by suppressing intestinal carbohydrate absorption and thereby reducing the postprandial increase of blood glucose.

PMID:
18618319
DOI:
10.1080/14756360801936399
[Indexed for MEDLINE]

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