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Dig Dis Sci. 2009 Mar;54(3):634-9. doi: 10.1007/s10620-008-0375-y. Epub 2008 Jul 11.

Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population.

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  • 1Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, 610041, Chengdu, Sichuan, Peoples' Republic of China.

Abstract

OBJECTIVE:

The purpose was to investigate single nucleotide polymorphism of the vitamin D receptor gene and its possible relationship with colorectal cancer (CRC) in a Chinese population.

METHODS:

The vitamin D receptor (VDR) genotypes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) using endonuclease BsmI and FokI, and direct sequencing in 400 Chinese people, comprised of 200 CRC patients and 200 controls from the same area in China.

RESULTS:

The distribution of alleles (F/f) and genotypes (FF/Ff/ff) of the FokI had no significant difference between CRC patients and normal controls (P > 0.05), while that of the B allele and the BB genotype of the BsmI in CRC patients was significantly lower compared with the control group (0.1625 versus 0.740, P < 0.05, OR = 0.068, 95% CI: 0.048-0.096 and 0.060 versus 0.590, P < 0.05, OR = 0.015, 95% CI: 0.007-0.032).

CONCLUSION:

The BB genotype of the VDR BsmI variant was significantly associated with a decreased risk of CRC in a Chinese population, while the VDR FokI polymorphism was not significantly associated with it.

PMID:
18618252
DOI:
10.1007/s10620-008-0375-y
[PubMed - indexed for MEDLINE]
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