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Cancer Immunol Immunother. 2008 Oct;57(10):1559-68. doi: 10.1007/s00262-008-0553-y. Epub 2008 Jul 10.

Dendritic cell vaccination and immune monitoring.

Author information

  • 1Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Abstract

We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC.

PMID:
18618110
PMCID:
PMC2491428
DOI:
10.1007/s00262-008-0553-y
[PubMed - indexed for MEDLINE]
Free PMC Article
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