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Nat Rev Immunol. 2008 Aug;8(8):619-30. doi: 10.1038/nri2357.

Impact of MHC class I diversity on immune control of immunodeficiency virus replication.

Author information

1
Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK. philip.goulder@ndm.ox.ac.uk

Abstract

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future.

PMID:
18617886
PMCID:
PMC2963026
DOI:
10.1038/nri2357
[Indexed for MEDLINE]
Free PMC Article

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