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Am J Respir Cell Mol Biol. 2008 Dec;39(6):644-7. doi: 10.1165/rcmb.2008-0169TR. Epub 2008 Jul 10.

MUC1 mucin: a peacemaker in the lung.

Author information

1
Immunology and Asthma Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108-5127, USA. kckim@LRRI.org

Abstract

MUC1 is a membrane-tethered mucin expressed on the surface of epithelial cells lining mucosal surfaces. Recent studies have begun to elucidate the physiologic function of MUC1 in the airways, pointing to an antiinflammatory role that is initiated late in the course of bacterial infection and is mediated through inhibition of TLR signaling. These new findings have great potential for clinical applications in controlling excessive and prolonged lung inflammation. This review briefly summarizes the protein structural features of MUC1 relevant to its function, the discovery of its antiinflammatory properties, and potential directions for future avenues of study.

PMID:
18617677
PMCID:
PMC2586042
DOI:
10.1165/rcmb.2008-0169TR
[Indexed for MEDLINE]
Free PMC Article
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