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Nature. 1991 Aug 1;352(6334):404-10.

Multiple modes of engrailed regulation in the progression towards cell fate determination.

Author information

1
Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448.

Abstract

The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.

PMID:
1861720
PMCID:
PMC2755087
DOI:
10.1038/352404a0
[Indexed for MEDLINE]
Free PMC Article

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