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Drug Discov Today. 2008 Nov;13(21-22):960-72. doi: 10.1016/j.drudis.2008.06.004. Epub 2008 Jul 19.

New challenges for pharmaceutical formulations and drug delivery systems characterization using isothermal titration calorimetry.

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1
Université Paris-Sud 11, School of Pharmacy, UMR CNRS 8612, 5 Rue J.B. Clément, 92296 Châtenay Malabry, France. Kawthar.bouchemal@u-psud.fr

Abstract

Long viewed as the 'method of choice' for characterizing thermodynamics and stoichiometry of molecular interactions, with high sensitivity, isothermal titration calorimetry (ITC) has been applied to many areas of pharmaceutical analysis. This review highlights ITC employment to measure binding thermodynamics and their use for pharmaceutical formulations and drug delivery system characterization particularly cyclodextrin-guest interactions, investigation of micellar-based systems, polyelectrolytes, nucleic acid interactions with multivalent cations and the optimization of DNA targeting and delivery. Furthermore, the potential of ITC for the characterization of different functionalities carried by nanoparticles as well as their interaction with living systems was outlined.

PMID:
18617012
DOI:
10.1016/j.drudis.2008.06.004
[Indexed for MEDLINE]
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