Format

Send to

Choose Destination
See comment in PubMed Commons below
FEMS Microbiol Lett. 2008 Aug;285(2):137-45. doi: 10.1111/j.1574-6968.2008.01263.x. Epub 2008 Jul 9.

Generating cell surface diversity in Candida albicans and other fungal pathogens.

Author information

1
Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

Abstract

The fungal cell surface contributes to pathogenesis by mediating interactions with host cells and eliciting host immune responses. This review focuses on the cell wall proteome of the major fungal pathogen Candida albicans and discusses how diversity at the cell surface can be introduced by altering the expression and structure of cell wall proteins. Remodelling the cell wall architecture is critical to maintain cellular integrity in response to different environments and stresses including challenge with antifungal drugs. In addition, the dynamic nature of the cell surface alters the physical properties of the fungal interface with host cells and thereby influences adhesion to the host and recognition by components of the host's immune system. Examples of the role of cell surface diversity in the pathogenesis of a number of microorganisms are described.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for Wiley
    Loading ...
    Support Center