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Annu Rev Cell Dev Biol. 2008;24:29-54. doi: 10.1146/annurev.cellbio.23.090506.123509.

Replicative aging in yeast: the means to the end.

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Department of Pathology, University of Washington, Seattle, Washington 98195, USA.


Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view on the development of yeast as a model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes aging still cannot be answered definitively, that day may be rapidly approaching.

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