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Endokrynol Pol. 2008 May-Jun;59(3):212-6.

The polymorphism in insulin receptor substrate-1 gene and birth weight in neonates at term.

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1
Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland. esimonska@op.pl

Abstract

BACKGROUND:

The mutation of the IRS-1 gene is one of the genetic risk factors which, it is speculated, is associated with insulin resistance or predisposition to type 2 diabetes. The aim of our study was to evaluate the association between the Gly972Arg polymorphism in the IRS-1 gene and birth weight in newborn children with adequate gestational age.

MATERIAL AND METHODS:

100 newborn children with adequate gestational age (38-42 weeks), whose mother had no disorders during pregnancy, were studied. Genomic DNA was extracted from umbilical cord blood leukocytes, and Gly972Arg polymorphism in the IRS-1 gene was genotyped using the PCR-based method.

RESULTS:

Birth weight was significantly lower in the newborn with the IRS-1 Gly972Arg polymorphism compared with a control group (3161.75 +/- 380.86 g vs. 3427.92 +/- 468.86 g). Body length and head circumference at birth were also lower in the neonates with that polymorphism (54.38 +/- 3.13 cm vs. 52.69 +/- 2.91 cm, and 34.08 +/- 1.47 vs. 33.63 +/- 0.81, respectively).

CONCLUSIONS:

The results suggest that the Gly972Arg genotype is associated with lower birth weight, body length and head circumference in neonates with adequate gestational age.

PMID:
18615395
[Indexed for MEDLINE]
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