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Acta Otolaryngol. 2009 May;129(5):481-6. doi: 10.1080/00016480802252243.

Effects of semicircular canal electrode implantation on hearing in chinchillas.

Author information

1
Department of Otolaryngology, Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

CONCLUSION:

Implantation of vestibular prosthesis electrodes in chinchilla semicircular canal ampullae can be accomplished without significant loss of cochlear function; however, the risk of hearing loss with the current surgical technique is high.

OBJECTIVES:

To determine if it is possible to implant vestibular prosthesis electrodes into the labyrinth without damaging hearing, and to quantify the extent of hearing loss due to implantation.

MATERIALS AND METHODS:

The left semicircular canals of six chinchillas were implanted with three bipolar pairs of electrodes using a transmastoid approach. Right ears, which served as controls, were subjected to the same mastoid approach without fenestration and implantation. Auditory brainstem response hearing thresholds to free-field clicks and tone pips at 2, 4, 6, and 8 kHz were measured bilaterally 3-9 weeks after implantation. Hearing thresholds were compared between sides and against data from six normal chinchillas.

RESULTS:

Four implanted ears suffered severe hearing loss, with thresholds ranging from 5 to 11 SD above the mean threshold of sham surgery control ears across all tested stimuli. Two implanted ears had preserved hearing, with thresholds remaining within 1 SD of the mean threshold of sham surgery control ears across nearly all stimulus frequencies.

PMID:
18615331
PMCID:
PMC2767272
DOI:
10.1080/00016480802252243
[Indexed for MEDLINE]
Free PMC Article

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