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Int J Occup Med Environ Health. 2008;21(2):165-72. doi: 10.2478/v10001-008-0015-y.

IL-18 levels in nasal lavage after inhalatory challenge test with flour in bakers diagnosed with occupational asthma.

Author information

1
Department of Occupational Diseases, Nofer Institute of Occupational Medicine, Łódź, Poland. annakrak@imp.lodz.pl

Abstract

OBJECTIVES:

The authors discuss the outcomes of a study on IL-18 concentration in nasal washings after the inhalatory challenge test with flour allergens (ICHT-F) in bakers with flour-induced occupational airway allergy (OAA).

METHODS:

We measured IL-18 concentration using ELISA kit and assessed morphological changes in nasal lavage fluid (NLF) before, and 4 h and 24 h after ICHT-F in three groups of subjects: Group A - 9 patients with diagnosed OAA (occupational asthma and rhinitis), Group B - 10 patients with atopic asthma and rhinitis, and Group C - 9 healthy volunteers.

RESULTS:

In Group A, significant differences in the basophil proportion in NLF were noted only 24 h after ICHT-F. Both the basophil proportion and total eosinophil count were higher in Group A than in Group C at this time-point. Group A also showed a statistically significant increase in IL-18 levels 4 h after the challenge. A significant relationship was noted between the proportion of basophils 4 h after ICHT-F and IL-18 level at 24 h after the test.

CONCLUSIONS:

This is the first study demonstrating an increased expression of IL-18 in nasal washings of subjects diagnosed with OAA to flour allergens. The observed higher concentrations of IL-18 in nasal washings after ICHT as well as the increase in the proportion of basophils provide evidence for the important role of IL-18 in persistent allergic inflammation.

PMID:
18614457
DOI:
10.2478/v10001-008-0015-y
[Indexed for MEDLINE]
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