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Drug Discov Today. 2008 Oct;13(19-20):842-55. doi: 10.1016/j.drudis.2008.05.007. Epub 2008 Jul 7.

Chemically modified siRNA: tools and applications.

Author information

1
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada. jonathan.watts@mail.mcgill.ca

Abstract

Chemical modification provides solutions to many of the challenges facing siRNA therapeutics. This review examines the various siRNA modifications available, including every aspect of the RNA structure and siRNA duplex architecture. The applications of chemically modified siRNA are then examined, with a focus on specificity (elimination of immune effects and hybridization-dependent off-target effects) and delivery. We also discuss improvement of nuclease stability and potency.

PMID:
18614389
DOI:
10.1016/j.drudis.2008.05.007
[Indexed for MEDLINE]

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