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Bioorg Med Chem Lett. 2008 Aug 1;18(15):4393-6. doi: 10.1016/j.bmcl.2008.06.057. Epub 2008 Jun 20.

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA. cheng_zhu@merck.com

Abstract

High-throughput screening revealed diaryl pyrazole 3 as a selective albeit modest cholecystokinin 1 receptor (CCK1R) agonist. SAR studies led to the discovery and optimization of a novel class of 1,2-diaryl imidazole carboxamides. Compound 44, which was profiled extensively, showed good in vivo mouse gallbladder emptying (mGBE) and lean mouse overnight food intake (ONFI) reduction activities.

PMID:
18614364
DOI:
10.1016/j.bmcl.2008.06.057
[Indexed for MEDLINE]

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