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Mol Cell. 2008 Jul 11;31(1):6-8. doi: 10.1016/j.molcel.2008.06.007.

mTOR and Akt signaling in cancer: SGK cycles in.

Author information

1
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. atoker@bidmc.harvard.edu

Abstract

In a recent issue of Molecular Cell, Hong et al. (2008) describe an alternative mechanism by which mTOR promotes cell-cycle progression; it phosphorylates and activates SGK, which in turn phosphorylates the cell-cycle inhibitor p27, promoting its cytoplasmic retention.

PMID:
18614042
DOI:
10.1016/j.molcel.2008.06.007
[Indexed for MEDLINE]
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