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Neuron. 2008 Jul 10;59(1):8-10. doi: 10.1016/j.neuron.2008.06.014.

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

Author information

1
Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany. mathias.jucker@uni-tuebingen.de

Abstract

In this month's issue of Nature Medicine, Town et al. suggest that peripheral macrophages invading the brain reduce cerebral amyloidosis and thus may play a key role in the pathogenesis of Alzheimer's disease (AD). This observation intensifies the longstanding controversy of whether mononuclear cells such as macrophages and/or microglial cells are beneficial or detrimental in AD.

PMID:
18614025
PMCID:
PMC2676343
DOI:
10.1016/j.neuron.2008.06.014
[Indexed for MEDLINE]
Free PMC Article

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