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Int J Antimicrob Agents. 1997 May;8(4):253-6.

HPLC residues of enrofloxacin and ciprofloxacin in eggs of laying hens.

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Farmacologia-Dpto. de Clinica Animal, Facultad de Agronomia y Veterinaria, Universidad Nacional de Rio Cuarto, Ruta 36, km 601, 5800-Rio Cuarto (Cba), Argentina.


Eggs of 12 laying hens with 5 mg/kg/day oral administration of 5% enrofloxacin (EFX) or ciprofloxacin (CFX) solution during 5 days contained residues from 0.02 to 1.98 microg/g (EFX) or 0.14 to 0.28 microg/g (CFX). At identical dosage regime High Performance Liquid Chromatograhy (HPLC) residues of EFX were 6-fold greater than CFX ones. Maximun concentrations were detected at the second day after the administration withdrawal. The limits of detection were 0.019 microg/g for EFX and 0.156 microg/g for CFX. The recovery was 36-50% for CFX and 49-85% for EFX. The withdrawal treatment periods in hens are six days for EFX and five days for CFX in order to avoid violative levels of egg residues.


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