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Med Mycol. 2008 Nov;46(7):631-6. doi: 10.1080/13693780802140907.

Dectin-1 and its role in antifungal immunity.

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Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Observatory, Cape Town, South Africa.


The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms. One such molecule is Dectin-1, a C-type lectin-like receptor which induces numerous cellular responses upon recognition of fungal beta-glucans. Here we review our current understanding of the functions of Dectin-1 and the underlying molecular mechanisms, as well as explore the role of this receptor in antifungal immunity.

[Indexed for MEDLINE]

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