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J Clin Exp Neuropsychol. 2008 Nov;30(8):931-45. doi: 10.1080/13803390801894681. Epub 2008 Apr 3.

Successful life outcome and management of real-world memory demands despite profound anterograde amnesia.

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Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA, USA.


We describe the case of Angie, a 50-year-old woman with profound amnesia (General Memory Index = 49, Full Scale IQ = 126) following a closed head injury in 1985. This case is unique in comparison to other cases reported in the literature in that, despite the severity of her amnesia, she has developed remarkable real-world life abilities, shows impressive self-awareness and insight into the impairment and sparing of various functional memory abilities, and exhibits ongoing maturation of her identity and sense of self following amnesia. The case provides insights into the interaction of different memory and cognitive systems in handling real-world memory demands and has implications for rehabilitation and for successful life outcome after amnesia.

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