Format

Send to

Choose Destination
Appl Microbiol Biotechnol. 2008 Sep;80(4):555-61. doi: 10.1007/s00253-008-1579-y. Epub 2008 Jul 8.

Lysostaphin: an antistaphylococcal agent.

Author information

1
Department of Biochemistry, National University of Singapore, Kent Ridge, Singapore. bchjkk@nus.edu.sg

Abstract

Lysostaphin is a zinc metalloenzyme which has a specific lytic action against Staphylococcus aureus. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-beta-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase. Glycylglycine endopeptidase specifically cleaves the glycine-glycine bonds, unique to the interpeptide cross-bridge of the S. aureus cell wall. Due to its unique specificity, lysostaphin could have high potential in the treatment of antibiotic-resistant staphylococcal infections. This review article presents a current understanding of the lysostaphin and its applications in therapeutic agent as a treatment against antibiotic-resistant S. aureus and methicillin-resistant S. aureus (MRSA) infections, either alone or in combination with other antibiotics.

PMID:
18607587
DOI:
10.1007/s00253-008-1579-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center