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J Biomech. 2008 Aug 7;41(11):2567-70. doi: 10.1016/j.jbiomech.2008.05.027. Epub 2008 Jul 7.

Remodeling of conduit arteries in hypertension and flow-overload obeys a minimum energy principle.

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1
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, 723 W. Michigan Street, Indianapolis, IN 46202, USA.

Abstract

Arterial remodeling is an important process in physiology and pathophysiology. Based on an energy minimization method, Murray's law predicts the optimal inner radius. Application of Darcy's law in the wall results in an optimal outer radius. The average wall stress is computed by the Laplace's law. Using these formulas, a large porcine coronary artery in hypertension is studied. The results reveal how wall thickness and average circumferential stress change after increasing blood pressure and volume flow rate. The theoretical predictions are in good qualitative agreement with experimental observations. The advantage and limitation of the current approach are discussed.

PMID:
18606418
PMCID:
PMC2628438
DOI:
10.1016/j.jbiomech.2008.05.027
[Indexed for MEDLINE]
Free PMC Article
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