Send to

Choose Destination
Dev Cell. 2008 Jul;15(1):11-22. doi: 10.1016/j.devcel.2008.06.006.

Signal-induced repression: the exception or the rule in developmental signaling?

Author information

Biozentrum der Universit├Ąt Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.


Cell-cell communication plays a key role in organ formation and patterning in multicellular animals and is carried out by a few evolutionarily conserved signaling pathways. The modes of action of these pathways share a number of general properties, or habits, that allow them to strongly activate target genes in a ligand-dependent manner in the proper cellular contexts. Recent studies have revealed that some developmental signaling pathways can also strongly repress genes in a ligand-dependent manner. These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center