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Dev Cell. 2008 Jul;15(1):1-2. doi: 10.1016/j.devcel.2008.06.005.

Targeting TGF-beta and the extracellular matrix in Marfan's syndrome.

Author information

1
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. rkalluri@bidmc.harvard.edu

Abstract

Marfan's syndrome is a genetic disorder affecting connective tissues, and it can lead to death due to aortic defects if left untreated. beta-blocker therapy has been used to slow the progression of this disease. Brooke et al. (2008) now report that combining angiotensin II receptor blockade by losartan with beta-blocker treatment is an effective treatment combination therapy for this disorder.

PMID:
18606132
DOI:
10.1016/j.devcel.2008.06.005
[Indexed for MEDLINE]
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