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J Perinat Med. 2008;36(5):419-24. doi: 10.1515/JPM.2008.062.

Pregnancy outcome of women who developed proteinuria in the absence of hypertension after mid-gestation.

Author information

1
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan. mmamoru@med.hokudai.ac.jp

Abstract

OBJECTIVE:

To characterize the clinical features of women with singleton pregnancies who develop proteinuria in the absence of hypertension after mid-gestation.

METHODS:

Seventy-nine women who developed proteinuria and/or hypertension at and after 20 weeks of gestation were reviewed, focusing on the gestational week at which significant proteinuria (>0.3 g/day) and/or hypertension developed.

RESULTS:

Thirty-seven (47%) women exhibited new-onset proteinuria (>0.3 g/day) in the absence of hypertension, 33 (42%) exhibited new-onset hypertension in the absence of proteinuria, and 9 (11%) exhibited both proteinuria and hypertension. Nineteen (51%) of 37 women who exhibited new proteinuria in the absence of hypertension and 5 (15%) of 33 women who exhibited new hypertension in the absence of proteinuria progressed to preeclampsia (P=0.002). Among women who exhibited new proteinuria, 10 (77%) out of 13 women and 9 (38%) out of 24 women who developed proteinuria at <32 weeks and >or=32 weeks, respectively, progressed to preeclampsia (P=0.022).

CONCLUSIONS:

Women with new-onset proteinuria in the absence of hypertension may be more likely to progress to preeclampsia than women with a presumptive diagnosis of gestational hypertension, and the likelihood of progression may be significantly greater among women with earlier presentation.

PMID:
18605971
DOI:
10.1515/JPM.2008.062
[Indexed for MEDLINE]

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