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J Natl Cancer Inst. 1970 Nov;45(5):989-95.

Relation between neutralization of Epstein-Barr virus and antibodies to cell-membrane antigens-induced by the virus.

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Laboratories at The Children's Hospital of Philadelphia, Pennsylvania, USA.


The neutralization of Epstein-Barr virus (EBV) infectivity by sera with known antibody activities against EBV-associated antigens was investigated in experimentally infected Raji and RPMI 64-10 cells. Antibodies against EBV-induced cell-membrane antigens were apparently responsible for neutralization of viral infectivity. Antibodies against EBV capsid antigens and EBV-induced early antigens were not involved. The implication of these results on the relationship of the membrane antigens to the infectious virus particle is discussed.

[Indexed for MEDLINE]

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