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Proteomics. 2008 Aug;8(15):3118-23. doi: 10.1002/pmic.200800084.

The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways.

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1
INSERM U567, Team21, Genetics and Development Department, Institut Cochin, Paris, France.

Abstract

The transcription factor Forkhead box L subfamily member 2 (FOXL2) is involved in craniofacial development and ovarian function. Using 2-DE and immunoblotting, we show that it is highly modified post-translationally. The most outstanding feature of its migration profile is the presence of two distinct modification "trains" and the absence of intermediates. A theoretical analysis of the modification profile of FOXL2 suggests that it undergoes parallel processive/concerted modifications. The absence of intermediates is compatible with the recruitment of poorly modified FOXL2 into a post-translational "modification factory."

PMID:
18604817
DOI:
10.1002/pmic.200800084
[Indexed for MEDLINE]
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