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Trends Cell Biol. 2008 Aug;18(8):360-3. doi: 10.1016/j.tcb.2008.06.001. Epub 2008 Jul 5.

Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice.

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Medical Research Council National Institute of Medical Research, Mill Hill, London, NW7 1AA, UK.


Glypicans are glycosylphosphatidylinositol-linked heparan sulfate proteoglycans that play an essential part in the regulation of morphogen signalling. Two new reports using Drosophila and mice have highlighted the importance of glypican endocytosis in the regulation of Hedgehog (Hh) signalling and in Wingless gradient formation. One Drosophila glypican, Dally-like, acts positively in Hh signalling, whereas mouse Glypican-3 is a negative regulator. This difference seems to be dependent on whether glypicans promote the internalization of Hh alone or as a complex with its receptor, Patched.

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