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Crit Care Med. 1991 Aug;19(8):1030-6.

Thermogenic and metabolic effects of dopamine in healthy men.

Author information

1
Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.

Abstract

OBJECTIVE:

To assess the thermogenic response of dopamine at three different infusion rates and to analyze its effects on various biochemical variables.

DESIGN:

Randomized sequential experimental treatment bracketed by control periods.

PATIENTS:

Eight young healthy male volunteers with normal body weight (51 to 89 kg).

INTERVENTIONS:

Three experimental periods during which dopamine was administered iv in a randomized order at rates of 2.5, 5, or 10 micrograms/kg.min with one preinfusion baseline and two recovery periods in between.

MEASUREMENTS AND MAIN RESULTS:

A significant (p less than .01) increase in resting energy expenditure was observed in response to the two highest dopamine infusion rates (5 and 10 micrograms/kg.min), corresponding to 6% and 15% median increases, respectively, as compared with preinfusion values. At the lowest dopamine infusion rate, no variation in resting energy expenditure was observed. Dopamine induced a significant (p less than .01) increase in hyperglycemia at all three infusion rates, and, at the highest infusion rate, dopamine induced a significant (p less than .05) increase of plasma free fatty acid concentrations. Insulin plasma concentrations were significantly (p less than .05 to p less than 0.1) increased at the three dopamine infusion rates.

CONCLUSIONS:

Dopamine infusion produces a dose-dependent thermogenic effect and induces various metabolic actions in man.

PMID:
1860327
[Indexed for MEDLINE]

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