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FEBS Lett. 2008 Aug 6;582(18):2689-95. doi: 10.1016/j.febslet.2008.06.048. Epub 2008 Jul 9.

Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis.

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1
Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-Sen University, Xin Gang Xi Road 135, Guangzhou 510275, PR China.

Abstract

In this study, we showed that curcumin treatment resulted in activation of Chk1-mediated G2 checkpoint, which was associated with the induction of G2/M arrest and the resistance of cancer cells to curcumin-induced apoptosis. Further investigation revealed that inhibition of Chk1 significantly abrogated G2/M arrest and sensitized curcumin-resistant cells to apoptosis via upregulation of Bad and in turn the loss of mitochondrial membrane potential. These results indicate that Chk1-mediated G2/M arrest may serve as a mechanism for curcumin resistance and Chk1 represents a potential target for the reversal of this resistance. Our findings should be helpful for clinical application of curcumin.

PMID:
18602917
DOI:
10.1016/j.febslet.2008.06.048
[Indexed for MEDLINE]
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