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Brain Res. 2008 Aug 28;1227:120-7. doi: 10.1016/j.brainres.2008.06.043. Epub 2008 Jun 21.

Intact interval timing in circadian CLOCK mutants.

Author information

1
Duke University, Department of Psychology and Neuroscience, Durham, NC 27708-90999, USA.

Abstract

While progress has been made in determining the molecular basis for the circadian clock, the mechanism by which mammalian brains time intervals measured in seconds to minutes remains a mystery. An obvious question is whether the interval-timing mechanism shares molecular machinery with the circadian timing mechanism. In the current study, we trained circadian CLOCK +/- and -/- mutant male mice in a peak-interval procedure with 10 and 20-s criteria. The mutant mice were more active than their wild-type littermates, but there were no reliable deficits in the accuracy or precision of their timing as compared with wild-type littermates. This suggests that expression of the CLOCK protein is not necessary for normal interval timing.

PMID:
18602902
PMCID:
PMC2613322
DOI:
10.1016/j.brainres.2008.06.043
[Indexed for MEDLINE]
Free PMC Article

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