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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Sep;106(3):392-402. doi: 10.1016/j.tripleo.2008.04.018. Epub 2008 Jul 7.

Labial salivary gland biopsies in Sjögren's syndrome: still the gold standard?

Author information

1
Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA. cstewart@dental.ufl.edu

Abstract

OBJECTIVES:

The accuracy and diagnostic benefits of the labial salivary gland (LSG) biopsy for Sjögren's syndrome (SS) have received mixed reviews. This study was conducted to assess (1) the inter-rater agreement among 5 pathologists, and (2) the relationship between biopsy findings and clinical disease parameters.

STUDY DESIGN:

Three oral pathologists (OP) and two surgical pathologists (SP) provided independent diagnoses, focus scores, and plasma cell characterizations for 37 LSG biopsies. Inter-rater reliability was assessed using percentage of overall agreement and intraclass correlation coefficients. Relationships between diagnoses and clinical parameters were assessed by nonparametric correlations.

RESULTS:

Overall agreement among the pathologists was poor, although the intra-specialty agreement was good. The ratings of OP were most highly correlated with serological measures, while those of SP were correlated with salivary flow rate and disease damage.

CONCLUSION:

Since the LSG biopsy can be the determining factor in SS diagnoses, these demonstrated inconsistencies merit further consideration.

PMID:
18602295
DOI:
10.1016/j.tripleo.2008.04.018
[Indexed for MEDLINE]

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