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Curr Opin Microbiol. 2008 Aug;11(4):305-12. doi: 10.1016/j.mib.2008.06.002. Epub 2008 Jul 17.

Host-microbe interactions: innate pattern recognition of fungal pathogens.

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Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.


The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen.

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