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Behav Brain Res. 2008 Dec 16;195(1):129-38. doi: 10.1016/j.bbr.2008.06.009. Epub 2008 Jun 12.

Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation.

Author information

1
Mental Health Institute of the 2nd Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011 Hunan, China.

Abstract

Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.

PMID:
18601957
DOI:
10.1016/j.bbr.2008.06.009
[Indexed for MEDLINE]

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