Format

Send to

Choose Destination
Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):711-5. doi: 10.3736/jcim20080710.

[Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study].

[Article in Chinese]

Author information

1
Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China. quxiaobing1@163.com

Abstract

OBJECTIVE:

To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro.

METHODS:

Seven male patients with kidney stones were admitted. Abdominal subcutaneous adipose tissue and perirenal adipose tissue were collected from the operating-patients, and were cultivated with different concentrations of curcumin (10 and 100 microg/ml) in vitro. The contents of APN and IL-6 in the culture medium of adipose tissue cells were measured by enzyme-linked immunosorbent assay (ELISA) after they were cultured for 6 and 24 hours.

RESULTS:

Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 microg/ml curcumin (P<0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 microg/ml curcumin after 6- and 24-hour culture (P<0.05).

CONCLUSION:

100 microg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.

PMID:
18601853
DOI:
10.3736/jcim20080710
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center