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J Biomed Opt. 2008 May-Jun;13(3):030504. doi: 10.1117/1.2937471.

Assessing the spatial extent of breast tumor intrinsic optical contrast using ultrasound and diffuse optical spectroscopy.

Author information

1
University of California, Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, Irvine, California 92612, USA.

Abstract

Little is known about the relationship between anatomic and functional contrast derived from intrinsic optical signals. In order to address this relationship, finite-element (FEM) forward simulations were compared to diffuse optical spectroscopy (DOS) reflectance measurements obtained from 10 breast tumor patients. Clinical ultrasound images were used to estimate anatomical tumor size and depth for the FEM simulations. Actual DOS-measured tumor absorption could not be matched by forward model simulations when tumor size was constrained to match ultrasound dimensions. However, agreement was achieved when the lesion was viewed as a distribution of optical properties (i.e., an extended target). This result suggests that the spatial extent of optical contrast in breast tumors may be significantly greater than anatomical dimensions reported by standard imaging modalities. Analysis indicates that invasive breast tumors with anatomical dimensions of 1 cm may still be detectable at depths of 30 mm or more (the center of the lesion to the surface of tissue) using DOS in a reflectance geometry.

PMID:
18601521
PMCID:
PMC2868508
DOI:
10.1117/1.2937471
[Indexed for MEDLINE]
Free PMC Article

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