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Cephalalgia. 1991 May;11(2):93-5.

Chocolate is a migraine-provoking agent.

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Bernhard Baron Memorial Research Laboratories, Queen Charlotte's and Chelsea Hospital, London.


Patients with migraine who believed that chocolate could provoke their attacks were challenged with either chocolate or a closely matching placebo. In a double-blind parallel group study, chocolate ingestion was followed by a typical migraine episode in 5 out of 12 patients, while none of the 8 patients challenged with placebo had an attack (p = 0.051). The median time to the onset of the attack was 22 h. This brief study provides some objective evidence that chocolate is able to provoke a migraine attack in certain patients who believe themselves sensitive to it.

[Indexed for MEDLINE]

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