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Brain Res. 1991 Apr 5;545(1-2):339-42.

Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury.

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Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905.


This experiment tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (alpha-CRF) was administered intraventricularly 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. alpha-CRF demonstrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.

[Indexed for MEDLINE]

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