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Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9337-42. doi: 10.1073/pnas.0801717105. Epub 2008 Jul 1.

Dependence of antibody-mediated presentation of antigen on FcRn.

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1
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.

PMID:
18599440
PMCID:
PMC2453734
DOI:
10.1073/pnas.0801717105
[Indexed for MEDLINE]
Free PMC Article

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