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Cancer Cell. 2008 Jul 8;14(1):10-21. doi: 10.1016/j.ccr.2008.06.001.

The HECT family of E3 ubiquitin ligases: multiple players in cancer development.

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1
Department of Experimental Medicine and Biochemical Sciences, Biochemistry IDI-IRCCS Laboratory, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Abstract

The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.

PMID:
18598940
DOI:
10.1016/j.ccr.2008.06.001
[Indexed for MEDLINE]
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