Format

Send to

Choose Destination
Brain Res Bull. 2008 Aug 15;76(6):605-11. doi: 10.1016/j.brainresbull.2008.02.024. Epub 2008 Mar 10.

Sleep improves the variability of motor performance.

Author information

1
IBM TJ Watson Research Center, Yorktown Heights, NY, United States.

Abstract

Sleep after learning often enhances task performance, but the underlying mechanisms remain unclear. Using a well-characterized rotation learning paradigm implemented both behaviorally and in computer simulations, we compared two main hypotheses: the first, that off-line replay during sleep leads to further potentiation of synaptic circuits involved in learning; the second, that sleep enhances performance by uniformly downscaling synaptic strength. A simple computer model implemented synaptic changes associated with rotation adaptation (30 degrees ), yielding a reduction in mean directional error. Simulating further synaptic potentiation led to a further reduction of mean directional error, but not of directional variability. By contrast, simulating sleep-dependent synaptic renormalization by scaling down all synaptic weights by 15% decreased both mean directional error and variability. Two groups of subjects were tested after either two rotation adaptation training sessions or after a single training session followed by sleep. After two training sessions, mean direction error decreased, but directional variability remained high. However, subjects who slept after a single training session showed a reduction in both directional error and variability, consistent with a downscaling mechanism during sleep.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center