Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2008 Aug;24(8):378-81. doi: 10.1016/j.tig.2008.05.007. Epub 2008 Jul 1.

Origin of introns by 'intronization' of exonic sequences.

Author information

1
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Barcelona 08028, Spain.

Abstract

The mechanisms of spliceosomal intron creation have proved elusive. Here we describe a new mechanism: the recruitment of internal exonic sequences ('intronization') in Caenorhabditis species. The numbers of intronization events and introns gained by other mechanisms are similar, suggesting that intronization significantly contributes to recent intron creation in nematodes. Intronization is more common than the reverse process, loss of splicing of retained introns. Finally, these findings link alternative splicing with modern intron creation.

PMID:
18597887
DOI:
10.1016/j.tig.2008.05.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center