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J Neurosci Methods. 2008 Aug 15;173(1):34-40. doi: 10.1016/j.jneumeth.2008.05.016. Epub 2008 May 28.

Wavelet filtering before spike detection preserves waveform shape and enhances single-unit discrimination.

Author information

1
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

The isolation of single units in extracellular recordings involves filtering. Removing lower frequencies allows a constant threshold to be applied in order to identify and extract action potential events. However, standard methods such as Butterworth bandpass filtering perform this frequency excision at a cost of grossly distorting waveform shapes. Here, we apply wavelet decomposition and reconstruction as a filter for electrophysiology data and demonstrate its ability to better preserve spike shape. For the majority of cells, this approach also improves spike signal-to-noise ratio (SNR) and increases cluster discrimination. Additionally, the described technique is fast enough to be applied real-time.

PMID:
18597853
PMCID:
PMC2602872
DOI:
10.1016/j.jneumeth.2008.05.016
[Indexed for MEDLINE]
Free PMC Article

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