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J Proteome Res. 2008 Aug;7(8):3254-66. doi: 10.1021/pr700751y. Epub 2008 Jul 3.

The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses.

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  • 1Rowett Research Institute, Bucksburn, Aberdeen, UK. sd@rri.sari.ac.uk

Abstract

Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of proteins involved in proliferation [e.g., PCNA], DNA repair [e.g., XRCC5, MSH2], apoptosis [e.g., BAG family chaperone protein, DIABLO and porin], cytoskeletal organization [e.g., actin, ezrin, elfin], and expression of proteins implicated in malignant transformation [COMT, Nit2].

PMID:
18597513
DOI:
10.1021/pr700751y
[PubMed - indexed for MEDLINE]
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