Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2008 Jul 16;19(11):1137-40. doi: 10.1097/WNR.0b013e3283063183.

Dopamine transporter inhibition is required for cocaine-induced stereotypy.

Author information

1
Department of Pharmacology, Ohio State University College of Medicine, Columbus, Ohio 43210, USA.

Abstract

The primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (DAT), norepinephrine, and serotonin. To dissect out the role of DAT in cocaine effects, we generated a knock-in mouse line with a cocaine-insensitive DAT (DAT-CI mice). DAT-CI mice provide a powerful tool that can directly test whether DAT inhibition is important for cocaine-induced stereotypy. We found that acute cocaine failed to produce stereotypy in DAT-CI mice. In fact, 40 mg/kg cocaine suppressed stereotypy in DAT-CI mice but produced profound stereotypy in wild-type mice. These findings suggest that DAT inhibition is necessary for cocaine-induced stereotypy. Furthermore, mechanisms independent of DAT inhibition appear to inhibit stereotypy.

PMID:
18596615
PMCID:
PMC3222591
DOI:
10.1097/WNR.0b013e3283063183
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Support Center